The purpose of the present study was to characterize the full-field ERG under both dark- and light-adapted conditions in 5xFAD mice to provide insight into rod- and cone-pathway dysfunction in these animals. The results show that (1) the ERG can be abnormal in 5xFAD mice, with the greatest deficits arising at post-receptor sites under dark-adapted conditions; (2) post-receptor abnormalities are observed under light-adapted conditions in the 5xFAD mice, but the abnormalities were generally less apparent relative to those observed under dark-adapted conditions and were restricted to ganglion cell dysfunction (inferred from measurement of the PhNR).
To our knowledge, this is the first report of full-field ERGs under light-adapted conditions in the 5xFAD mouse. The light-adapted a- and b-waves were normal in these animals, suggesting that cone photoreceptor function and signal…
