Potential drug for Alzheimer’s disease prevention found safe and effective in animals

Potential drug for Alzheimer's disease prevention found safe and effective in animals
Compared with a control (left), treatment with the novel GSM (right) reduces the number of amyloid plaques (green) and proinflammatory cells called microglia (magenta) in the brains of mice carrying mutations linked to early-onset Alzheimer’s disease. Credit: ©2021 Rynearson et al. Originally published in Journal of Experimental Medicine. 10.1084/jem.20202560

Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer’s disease by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques in the brain. The study, which will be published March 2 in the Journal of Experimental Medicine (JEM), demonstrates that the drug is safe and effective in rodents and…

Read more…