Scientists like the John A. Moran Eye Center’s Paul S. Bernstein, MD, PhD, know a special class of lipids, or fatty acids, found in the retina of the eye and in just a few other parts of the body play an important role in maintaining vision.
But it’s been difficult to study whether giving these lipids, called very-long-chain polyunsaturated fatty acids (VLC-PUFAs), to patients as a supplement could prevent blinding eye diseases like age-related macular degeneration, diabetic retinopathy, and some inherited retinal diseases. Made in the body by the ELOVL4 enzyme but rarely consumed as part of a normal diet, VLC-PUFAs weren’t commercially available in enough quantities for animal or human research.
Now Bernstein and colleagues from the University of Utah’s Chemistry Department have changed the paradigm, inventing a method for synthesizing large enough quantities of VLC-PUFAs to…
