If you’ve ever forgotten something mere seconds after it was at the forefront of your mind — the name of a dish you were about to order at a restaurant, for instance — then you know how important working memory is. This type of short-term recall is how people retain information for a matter of seconds or minutes to solve a problem or carry out a task, like the next step in a series of instructions. But, although it’s critical in our day-to-day lives, exactly how the brain manages working memory has been a mystery.
Now, Salk scientists have developed a new computational model showing how the brain maintains information short-term using specific types of neurons. Their findings, published in Nature Neuroscience on December 7, 2020, could help shed light on why working memory is impaired in a broad range of neuropsychiatric disorders, including schizophrenia, as well as in normal…
