Study population characteristics (model selection sample)
A total of 148 patients with MCI from the Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) cohort for whom all three plasma and CSF biomarker measurements were available, along with at least one of the primary or secondary outcomes, were used for model selection (Table 1). The mean age was 71.4 years, the mean education duration was 11.2 years, 36.5% were female and the mean mini-mental state examination (MMSE) score was 27.2 ± 1.7 at the baseline. Moreover, the mean MMSE score was 21.8 ± 5.2 at 4 years after the baseline and conversion to AD dementia was 59.8% within 4 years of the baseline. There was a significant negative correlation between plasma Aβ42/Aβ40 and plasma P-tau181 (coefficient of determination (R2) = −0.30; P < 0.0001; see Extended Data Fig. 1) and a…
