Scientists have discovered how drug-like small molecules can regulate the activity of therapeutically relevant ion channels — and their findings could transform ongoing drug development efforts.
A major mechanism by which cells communicate with their environment is the movement of metal ions through channels located within their cell membranes.
The new study by researchers at the University of Leeds, published today in Communications Biology, provides detailed insight into the regulation of TRPC5 ion channels, which allow positively charged ions such as calcium, sodium and potassium to flow in and out of cells.
TRPC5 channels are considered potential therapeutic targets for the treatment of a range of conditions, including anxiety, kidney disease and cardiovascular disease.
Led by Dr Robin Bon, Associate Professor of Chemical Biology in the School of Medicine, and Dr Stephen Muench,…
