Participants
We enrolled 645 patients (129 SCI, 270 AMCI, and 246 ADD) who were followed up more than three times to obtain CDR-SB scores at the Samsung Medical Center from Jan. 2003 to Dec. 2015. Experienced neurologists evaluated the participants based on their clinical symptoms and reviews of medical/medication history, neuropsychological test results, magnetic resonance imaging (MRI), and laboratory tests. ADD patients met the criteria proposed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA)32. The diagnosis of AMCI was based on the criteria proposed by Peterson and colleagues33 with inclusion of the following modifications: (1) Subjective cognitive complaints by the patient or his/her caregiver, (2) normal activities of daily living, (3) objective memory decline…
