Despite the important advances in research in recent years, the etiopathogenesis of Alzheimer’s disease is still not fully clarified. One of the key questions is to decipher why the production of beta amyloid, the protein that produces the toxic effect and triggers the pathology, increases in the brain of people with Alzheimer’s.
The research has so far focused on fragments of the amyloid precursor protein (APP), but the results have been inconclusive. “This is because this protein is processed so quickly that its levels in the cerebrospinal fluid or in the plasma do not reflect what is really happening in the brain,” explains…