Over one hundred years since psychiatrist Alois Alzheimer described the hallmarks of the disease that bears his name, significant gaps in our understanding of how and why the disease develops mean that we still do not have effective treatments.
Alzheimer identified deposits of protein that had accumulated in the brain of a patient who died from dementia. In the years since, research has heavily focussed on the fragments of protein, known as amyloid-beta, that form these…