Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer’s disease neuropathology

Data source

Data used in this study were obtained from the National Alzheimer’s Coordinating Center (NACC), which co-ordinates data collection across a network of 39 past and present Alzheimer’s Disease Centers (ADCs) across the USA. ADC participants complete roughly annual clinical evaluations according to a standardized protocol, with data collected in the Uniform Data Set (UDS)¹³, which comprises detailed assessments including physical and neurological exams, a neuropsychological test battery, and questionnaires that assess neuropsychiatric symptoms, family history, functional abilities, medical history, and medication use. A subset of participants who consent to autopsy undergo standardised neuropathological examination which contribute to the Neuropathology Data Set. UDS data collected from September 2005 to December 2018 were used in this study. Research using the NACC…