The preclinical amyloid sensitive composite to determine subtle cognitive differences in preclinical Alzheimer’s disease

We investigated the distinct neuropsychological features of Aβ+ CN elderlies in a carefully phenotyped, CN cohort that underwent detailed neuropsychological tests, MRI, and amyloid PET scans with the standardized protocols. Accordingly, there were several significant neuropsychological findings in this study. First, the MIMIC model found the latent mean difference between the Aβ+ and Aβ− groups in the domains of verbal memory, visual memory, and executive functions. Furthermore, MANCOVA showed that the Aβ+ group performed worse in the SVLT-E delayed recall, the RCFT delayed recall, the K-CWST color reading, and the COWAT animal naming within the three cognitive domains. The PASC model that we developed using the result of MANCOVA and the MMSE presented a good fit with the data. Finally, the accuracy of the PASC score when applied with age, sex, education, and APOE ε4…