Projecting early molecular signatures of AD through the convergence study of omics and AI

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Credit: Unsplash/CC0 Public Domain

The Korea Brain Research Institute (headed by Suh Pann-ghill) announced on July 24 the discovery that an increase in amyloid-beta in the brain alters cholesterol biosynthesis, which was found by Dr. Cheon Mookyung of KBRI through RNA-seq analysis data (omics) using AI.

The research results were published in PLOS Computational Biology, an international academic journal in the field of computational biology.

Amyloid-beta is known as a protein that causes Alzheimer’s disease (AD). In a normal brain, if it accumulates excessively, it is removed by microglia, etc. Cholesterol must also be kept at a certain level within the blood to…

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