Newswise — Irvine, CA – July 21, 2020 – Patients with Alzheimer’s disease frequently suffer from spatial memory loss, such as no recognition of where they are, and forgetting where they put their belongings. They often show a wandering symptom, which is also a feature of spatial memory impairment. Until now, the brain network mechanism that causes spatial memory impairment had been unclear.
Published today in Neuron, the study titled, “Disrupted place cell remapping and impaired grid cells in a knockin model of Alzheimer’s disease,” reveals how the normal brain network function of hippocampus cells which works to discriminate a distinct spatial environment in a process called “remapping,” was disrupted in Alzheimer’s disease. The study, done Alzheimer’s disease model mice, found that this disruption of hippocampus is most likely caused by the activity…
