[18F]-Florbetapir uptake is significantly higher in the 5xFAD brain
We first assessed amyloid load in the whole brains (identified as intracranial activity) of 5xFAD mice compared to WT mice by measuring [18F]-Florbetapir uptake by PET-CT. Uptake was significantly greater in the 5xFAD whole brain (Fig. 1B) as has been previously reported (p = 0.0055). CT scanning (Fig. 1B, top panel) enables visualization of the skull to identify the brain but does not resolve specific brain regions. The PET scans for both PET-CT and PET-MRI are quantitative, meaning that they are parameterized in terms of percent of the injected dose per gram of tissue (%ID/g), with yellow to white pseudocolors corresponding to the highest %ID/g values and blue to black colors the lowest values. All PET images are thus quantitatively comparable. Of note, tracer uptake is very high in the eyes and area…
