A study led by the Institut de Neurociències (INc-UAB) shows that APOE4, the principal genetic risk factor for the most common type of Alzheimer’s disease, produces an alteration in the astrocytes’ signaling mechanisms in male mice, which could be key for the development of this pathology. In females, however, this alteration occurs in different variants of APOE. The study advances the description of APOE functions in the brain, and the understanding of its role in the development of the illness. At the same time, it shows how Alzheimer’s can affect each gender differently.
The Apolipoprotein gene (APOE) can occur in three…
