Purpose
To evaluate the psychometric properties and patterns of decline on the total score and item scores of the cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) in patients with Alzheimer Disease (AD).
Methods
We analyzed data from 536 AD outpatients randomized to the placebo group in two identical 26-week multicenter drug trials.
Results
Mean deterioration at week 26 on the ADAS-Cog total score for subjects with moderate dementia was 84% greater than that for those with milder severity (p < 0.001). After adjusting for this effect, age (p = 0.015) and educational level (p = 0.01) also predicted cognitive decline. In a model, absolute change for most individual ADAS items was less than 10% of the possible change, and it was generally smaller than one-third of the standard deviation of the measure. Measurement error variability was greatest for word…
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