Study design
This study was a sub-analysis of data from the gerontological investigation of microbiome: a longitudinal estimation study (the Gimlet study) at the National Center for Geriatrics and Gerontology (NCGG)4. The present sub-analysis study investigated the cross-sectional association between metabolites of the gut microbiome and dementia. The study complied with the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board at the NCGG (No. 1191). Informed consent was obtained from all patients and their families before participating in this study. The study is registered with the UMIN Clinical Trials Registry (UMIN000031851). Detailed information regarding the Gimlet study and the study methods is provided in the supplementary file and the previous report4.
Subjects
Between March 2016 and March 2017, we enrolled consecutive patients visiting the…
