Protein shapes matter in Alzheimer’s research

Protein shapes matter in Alzheimer's research
Cellular toxicity, which is higher in amyloid amorphous aggregates, shows that small changes in protein folding chemistry can cause differences in shape and toxicity. Credit: Ashutosh Tiwari

Sometimes proteins misfold. When that happens in the human brain, the pileup of misfolded proteins can lead to neurodegenerative diseases like Alzheimer’s, Parkinson’s and ALS.

Proteins do not misbehave and misfold out of the blue. There is a delicate ecosystem of biochemical interactions and environments that usually let them twist, unfold, refold and do their jobs as they’re meant to.

However, as researchers from Michigan Technological University explore in an article published in ACS Chemical Neuroscience,…

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