Participants
We studied 124 AD, 103 aMCI, and 49 HC from an ongoing project, recruited from memory clinics in the National University Hospital, Saint Luke’s Hospital and nearby communities52,53. Diagnoses were made by psychologists, neurologists, and research personnel at weekly consensus meetings based on clinical observation, lab tests (e.g., blood test), neuroimaging scans and neuropsychological assessments. Accordingly, participants fulfilling the criteria of National Institute of Neurological and Communicative Diseases and Stroke-Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA)54 were identified as AD. aMCI patients were identified if participants had both subjective cognitive complaint and objective impairment in at least the memory domain (see Clinical and neuropsychological assessments), but not demented and remained functionally independent. Finally,…
