(HealthDay)—Klotho-VS heterozygosity (KL-VSHET+ status) is associated with a reduced risk for Alzheimer disease (AD) and β-amyloid (Aβ) burden in cognitively normal individuals aged older than 60 years who carry apolipoprotein e4 (APOE4), according to research published online April 13 in JAMA Neurology.
Michael E. Belloy, Ph.D., from Stanford University in California, and colleagues combined 25 independent case-control, family-based, and longitudinal AD cohorts that recruited referred and volunteer participants to examine whether KL-VSHET+ status is associated with reduced AD risk and Aβ pathology. There were 36,530 eligible participants, of whom 13,782 were excluded; analyses were stratified by APOE4 status.
The…
