Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies. Arakhamia et al. use cryo-electron microscopy and mass spectrometry to compare the structures of tau filaments from corticobasal degeneration and Alzheimer’s disease, identifying the importance of posttranslational modifications in mediating the structural diversity of tauopathy strains. Above: Tau filaments decorated with ubiquitin chains (yellow) from corticobasal degeneration (blue/navy) and Alzheimer’s disease (red/purple) emanating from a neuron. Credit: Veronica Falconieri Hays and Anthony Fitzpatrick/Columbia University’s Zuckerman Institute
The protein tau has long been implicated in Alzheimer’s and a host of other debilitating brain diseases. But scientists have struggled to understand exactly how tau converts from its…
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