Study design and study centres
CSF analyses had been planned in Göttingen before 472 samples were collected from four European centres in the framework of a retrospective case-control study design. The case selection was based on the availability of samples from patients with the target conditions (VaD and important differential diagnoses) and complete information for clinical criteria application (including basic CSF analyses and neuroimaging). Patients with central nervous system inflammation and neoplasia (possible causes for white matter pathology) as well as intermediate diagnostic categories (e.g. possible AD, CJD, DLB etc.) were excluded. CSF LCN2 analyses (index test) were performed in Göttingen blind to diagnoses in 2018.
Cohort 1 was recruited at the Clinical Dementia Center and the National Reference Center for Creutzfeldt-Jakob disease surveillance at the University…
