Datasets
Our analysis was conducted on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset publicly available at (adni.loni.usc.edu). The initiative was launched in 2003 as a public-private partnership, led by Principal Investigator Michael W. Weiner, MD (see www.adni-info.org for updates). To match the aim of our study, we combined two types of ADNI datasets:
- (1)
DWI volumes was taken at two-time points, at the baseline and after 12 months (we refer to this as follow-up). In this set, we used a cohort comprised of 31 Alzheimer’s disease patients (age: 76.5 ± 7.4 years), and 49 healthy elderly subjects (77.0 ± 5.1) matched by age, as well as 57 MCI subjects (age: 75.34 ± 5.93).
- (2)
The PLINK binary files (BED/BIM/FAM) genotypic data for AD, controls and Early MCI.
The DWI and T1-weighted were obtained by using a GE Signa scanner 3 T (General Electric, Milwaukee, WI,…
