Clusters identified in the ADNI database
The 3C methodology progresses in three major steps, where the results of earlier steps serve the following ones. In the Categorize step, the 144 clinical characteristics were screened for association with the assigned diagnosis, and the leading 12 as indicated by VSURF16 were selected for unsupervised clustering. Those included: Clinical Dementia Ratings scales of memory, global score, sum of boxes, judgement, Mini Mental Status Examination (MMSE) total score, sum of memory scores, Functional Activities Questionnaire total score, Everyday Cognition study partner’s and participant’s assessment of memory and participant’s overall score, Functional Activities Questionnaire, The Alzheimer’s Disease Assessment Scale overall score and delayed recall/memory score. The original ADNI data consisted of 5 diagnosis groups: AD (Alzheimer’s…
