Reelin reverts the main pathological processes related to Alzheimer’s and other tauopathy

Reelin reverts the main pathological processes related to Alzheimer’s and other tauopathy
Image of a primary neuronal cell culture with detection of MAP2 dendritic marker (red) and Neurofilament axon marker (green). Credit: University of Barcelona

Promoting the signaling pathway of reelin, an essential extracellular protein for the neuronal migration and synaptic plasticity, could be an effective therapeutic strategy to counterbalance the main cognitive, biochemical and behavioural alterations seen in Alzheimer’s and other pathologies associated with Tau protein, as shown in a new study with animal models published in the journal Progress in Neurobiology.

The study proves the determining role of reelin in the modulation of pathological processes associated with Alzheimer’s and other…

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