Samples, genotyping, and imputation
Data used in the preparation of this article were obtained from the ADNI database (http://www.loni.ucla.edu/ADNI). The Illumina SNP genotyping data, demographic information, APOE genotype and baseline diagnosis information from 754 ADNI-1 participants, including 213 cognitive normal individual controls, 175 AD patients, and 366 patients with mild cognitive impairment (MCI) were downloaded from ADNI database. All participants provided written informed consent and study protocols were approved by participating sites’ Institutional Review Board.
SNP genotyping of 620,901 markers on ADNI-1 participants were generated using Illumina BeadStudio 3.2 software from bead intensity data. All SNP genotypes are publicly available for download at the ADNI website. For genotype imputation analysis, only SNPs fulfilling the following criteria were included (1)…
