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Fig. 1
Longitudinal T1-weighted signal intensity follow-up after one injection of Gd chelates in the hippocampus and globus pallidus in the living human brains. (A) Representative blood-brain barrier (BBB) Ktrans maps of the whole brain in an older participant with no cognitive impairment (NCI). (B) Representative BBB Ktrans maps in the hippocampus and globus pallidus in a young NCI (upper row) and a participant with mild cognitive impairment (MCI; lower row). (C and D) Overlaid scatterplots and box-and-whisker plots showing quantification of BBB Ktrans values in the hippocampus (C) and globus pallidus (D) in young NCI (n = 6, ages 23-47, both genders), older NCI (n = 40,…
