Eating more ketones may fight against Alzheimer’s disease

Eating more ketones may fight against Alzheimer's disease
Decreased levels of SIRT3 triggers loss of interneurons in Alzheimer’s disease mouse models. Credit: Cheng et al., JNeurosci 2019.

A ketone-supplemented diet may protect neurons from death during the progression of Alzheimer’s disease, according to research in mice recently published in JNeurosci.

Early in the development of Alzheimer’s , the brain becomes over excited, potentially through the loss of inhibitory, or GABAergic, interneurons that keep other neurons from signaling too much. Because interneurons require more energy compared to other neurons, they may be more susceptible to dying when they encounter the Alzheimer’s disease protein . Amyloid beta has been shown to…

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