Amyloid-β-independent regulators of tau pathology in Alzheimer disease

Hardy, J. & Allsop, D. Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol. Sci. 12, 383–388 (1991).

Selkoe, D. J. The molecular pathology of Alzheimer’s disease. Neuron 6, 487–498 (1991).

Ringman, J. M. et al. Neuropathology of autosomal dominant Alzheimer disease in the National Alzheimer Coordinating Center Database. J. Neuropathol. Exp. Neurol. 75, 284–290 (2016).

Gordon, B. A. et al. Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers. Brain 142, 1063–1076 (2019).

Quiroz, Y. T. et al. Association between amyloid and tau accumulation in young adults with autosomal dominant Alzheimer disease. JAMA Neurol. 75, 548–556 (2018).

Schöll, M. et al. Distinct ¹⁸F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer’s disease. Brain 140,…