Animals
All procedures were approved by the McGill University Animal Care Committee and the Canadian Council on Animal Care. Male mice expressing a mutant form of the human amyloid protein precursor bearing both the Swedish (K670N/M671L) and the Indiana (V717F) mutations (APPSwInd) under the control of the PDGFB promoter [B6. Cg-Tg(PDGFB-APPSwInd)28, (Jackson laboratory)] were bred with female parvalbumin-cre mice (Jackson Laboratory). This mouse line is termed PVJ20 throughout the current study. A total of n = 87 PVJ20 mice were used in this study (n = 44 PVJ20 + , n = 43 PVJ20−). n = 31 mice were implanted with fiber optic implants to perform combined optogenetics and freely moving behavior, n = 6 mice were implanted with linear silicon probes, n = 40 mice were implanted with electrode arrays, and n = 10 mice were used for patch-clamp…
