Individualized clinical management of patients at risk for Alzheimer’s dementia

Jump to Section1. Introduction2. Methods  2.1. Study design and participants  2.2. Procedures  2.3. Outcomes  2.4. Statistical analyses    2.4.1. General    2.4.2. Mixed model repeated measures (MMRM)    2.4.3. Historical comparison    2.4.4. Compliance adjusted model    2.4.5. Exploratory analyses3. Results  3.1. Disposition  3.2. Demographics and baseline characteristics  3.3. MMRM for primary outcome—m-APCC    3.3.1. Compliance by diagnosis group (Prevention vs. Treatment) interaction    3.3.2. Historical comparison for the primary outcome  3.4. Adjustment for baseline factors predictive of compliance    3.4.1. Predictors of compliance  3.5. Secondary endpoints    3.5.1. Cognitive aging changes (non–AD-specific)    3.5.2. Risk scales    3.5.3. Serum risk biomarkers  3.6. Safety analysis4. Discussion5. Conclusion

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