Collection of human AD tissue and controls
All tissue donors were neurologically and psychometrically studied at the Alzheimer Disease Research Center (ADRC) at the University of California, San Diego (UCSD). Three patients, AD1 (female, 70 years, Braak stage VIB), AD2 (male, 76 years, Braak stage VI) and AD3 (female, 84 years, Braak stage VI), showed severe AD and CAA. In all three cases, affected blood vessels were thickened and hyalinized. Upon autopsy, patient brains were collected by the UCSD ADRC Neuropathology Core. The brain weight was 884 g (AD1), 1134 g (AD2) and 988 g (AD3). The brains were sagittally divided at autopsy. The left hemibrain was fixed in 10% (v/v) formalin in water for neuropathological analysis, while the right hemibrain was frozen at −70 °C. Meningeal tissue overlying the cerebral cortex was collected from AD1−3 and from one control case…
