Intermediates of NO metabolism and dementia
As compared to control individuals, patients with dementia had significantly higher SDMA and DMA concentrations and lower ADMA, arginine-to-ADMA ratio (Arg/ADMA), L-arginine, and L-citrulline (further referred to as arginine and citrulline) (Fig. 1).
Intermediates of NO metabolism in patients with and without dementia: (a) arginine; (b) ADMA; (c) SDMA; (d) citrulline; (e) DMA; (f) Arg/ADMA. Data analyzed using t-test for independent samples. Geometric mean values and 95% confidence interval are given below the dot-plots and presented graphically by inverse triangles and whiskers.
Since there was significant difference in age distribution between groups, data were re-analyzed using analysis of covariance (ANCOVA) with age as a covariate. With age differences accounted for, arginine (p = 0.014 for age and p < 0.001 for dementia),…
