Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

By
dementianews
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In this study, we used the SOMAscan assay to measure 4001 proteins in plasma in two groups of subjects from the EMIF-AD MBD study. Using machine learning, we identified a panel of 44 proteins that, along with age and APOE ε4, predicted measures of central amyloid with good performance in both the discovery group (AUC = 0.78) and the replication group…

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