Patients with mild Alzheimer’s have had a deep brain stimulation (DBS) system implanted in this study to evaluate the safety and potential clinical benefit of DBS of the fornix (DBS-f), a major inflow and output pathway in the brain’s memory circuit. The ADvance Study is the only double-blind randomized and controlled trial and the largest study ever conducted of DBS for Alzheimer’s. Top-line outcomes data are expected in the second quarter of 2015.