Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer’s disease and three causality networks: The GR@ACE project

Jump to Section1. Background2. Methods  2.1. Subjects    2.1.1. GR@ACE cohort and phenotype definitions    2.1.2. Replication sample  2.2. GWAS genotyping, quality control, imputation, and statistical analysis  2.3. Genetic exploration of GR@ACE clinical endophenotypes and enrichment analysis  2.4. Meta-analysis: Data sets and association analysis  2.5. Replication of genome-wide significant findings  2.6. Biological interpretation of meta-GWAS signals3. Results  3.1. GR@ACE genome-wide association study  3.2. Genetic exploration of GR@ACE clinical endophenotypes and enrichment analysis  3.3. Meta-analysis of GR@ACE study with other data sets  3.4. Replication of genome-wide significant findings  3.5. Biological interpretation of meta-GWAS signals4. DiscussionSupplementary dataReferences

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