Assessing cost-effectiveness of early intervention in Alzheimer’s disease: An open-source modeling framework

The change in focus for the development of DMTs from dementia states to the predementia stage of AD implies, in the absence of the identification of high-risk groups, treating a large “at risk” population of which only a subset would progress over time to dementia. However, against this potentially expensive evaluative setting, we find that when modeling a treatment scenario, there is a clear and unambiguous potential benefit from treatment, with extended time in the predementia health state and a reduction in time…