Overall expression profile of mRNA, miRNA, and circRNA
Among a total of 39,429 mRNAs analyzed, the number of differentially expressed mRNAs in the brain of 7 M Tg2576 mouse was 1,108 (up-regulated, 417; down-regulated, 691) and 12 M mouse was 1,534 (up-regulated, 1,121; down-regulated, 413). Scatter plots for the mRNA expression pattern were demonstrated in Fig. 1A. In most cases, dysregulation of mRNAs was time specific, not persisting or being reversed between 7 M and 12 M (2186/2414, 90.6%, Fig. 2A). Top five most dysregulated mRNAs in 7 M and 12 M Tg2576 mice were listed in Table 1. The full data of mRNAs expression is available in Supplemental Data S1.
Microarray data analysis of the differentially expressed mRNAs and circRNAs in the brain of Alzheimer’s disease model. Scatter Plot (panel A) shows the distribution of the expression levels of mRNAs in the…
