Acute stress rescues impaired LTP in the hippocampal CA1 region of AD mice
In the first set of experiments, we determined whether acute stress alters LTP in the CA1 region by recording fEPSPs in acutely prepared hippocampal slices from either 5XFAD or Tg2576 mice (Fig. 1a). The baseline recordings were stable for 30 min, with no significant difference between stressed and control unstressed mice. However, further recordings for 60 min following HFS revealed that LTP was not induced in slices from control 5XFAD (n = 6 [six slices from six animals per group]) or control Tg2576 (n = 6) mice (Fig. 1b,c, respectively). By contrast, LTP was induced by HFS in slices from stressed 5XFAD [t = −6.855, df = 9; p < 0.01, n = 6, unpaired t test; Fig. 1b] and stressed Tg2576 [t = −11.135, df = 6; p < 0.01, n = 6, unpaired t test; Fig. 1c] mice….
