Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology

Jump to Section1. Introduction2. Methods  2.1. Participants  2.2. CSF measurements and classification  2.3. APOE genotyping  2.4. Analytic methods    2.4.1. Training and validation sets    2.4.2. LASSO regression modeling of baseline cognitive performance    2.4.3. Applying model weights to predict clinical diagnostic category    2.4.4. Using weighted marker scores to predict 4-year cognitive trajectory  2.5. Data availability3. Results  3.1. Demographic characteristics  3.2. AD biomarkers’ and CSF proteins’ relation to cognitive scores  3.3. LASSO protein model weights predict diagnostic category  3.4. Weighted marker score predicts rate of 4-year cognitive decline4. Discussion  4.1. Function of the predictive CSF proteins  4.2. Strengths and limitations  4.3. A hypothesis and experimental approaches to its assessmentReferences

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