(HealthDay)—Plasma β-amyloid (Aβ)42/Aβ40 corresponds with amyloid positron emission tomography (PET) status, according to a study published online Aug. 1 in Neurology.
Suzanne E. Schindler, M.D., Ph.D., from the Washington University School of Medicine in St. Louis, and colleagues measured Aβ42/Aβ40 in plasma and cerebrospinal fluid (CSF) samples obtained from 158 mostly cognitively normal individuals within 18 months of an amyloid PET scan.
The researchers identified high correspondence for plasma Aβ42/Aβ40 with amyloid PET status (receiver operating characteristic area under the curve [AUC], 0.88) and CSF p-tau181/Aβ42 (AUC, 0.85). There was a very high correspondence for the combination of plasma Aβ42/Aβ40,…
