Researchers develop miniature brain models to study Alzheimer’s causes and test drug development

City of Hope researchers develop miniature brain models to study the causes of Alzheimer’s disease and to test drugs in developm
The stereo image (left) and immunostaining image (right) of brain organoids (BO) at Day 50. Green: TUJ1, red: SOX2. Credit: City of Hope

Researchers led by City of Hope, a world-renowned research and treatment center for cancer, diabetes and other life-threatening diseases, have developed a powerful miniature brain platform to study the mechanistic causes of Alzheimer’s disease and to test dementia drugs in development, reports a new study published today in Advanced Science.

“Drug development for Alzheimer’s disease has run into challenges due to incomplete understanding of the disease’s pathological mechanisms,” said Yanhong Shi, Ph.D., the Herbert Horvitz…

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