15 novel biomarkers for diseases predisposing to dementia discovered

Study: 15 novel biomarkers for diseases predisposing to dementia discovered
Flowchart of sample selection in discovery and validation cohorts. ARIC, the Atherosclerosis Risk in Communities study. Credit: DOI: 10.1002/alz.12419

A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset.

The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin resistance. Six of these proteins can be modified with currently available medications prescribed for conditions other than

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