A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer’s disease
CohortsThe main dataset used in this study comes from the ROS/MAP cohorts. ROS and MAP are longitudinal cohort studies of aging and AD led by investigators at the Rush Alzheimer’s Disease Center51,52. Participants give...
Hearing difficulty is linked to Alzheimer’s disease by common genetic vulnerability, not shared genetic...
1.World Health Organization. Dementia. Available at: https://www.who.int/news-room/fact-sheets/detail/dementia (2019).2.World Health Organization. Addressing the rising prevalence of hearing loss. (2018). Available at: http://www.who.int/pbd/deafness/estimates/en/ (2018).3.Gates, G. A. & Mills, J. H. Presbycusis. Lancet (Lond., Engl.) 366, 1111–1120...
For Concussion Patients, CTs Offer Window into Recovery
This post was authored by Suzanne Leigh, senior public information representative with UCSF News.
CT scans for patients with concussion provide critical information about their risk for long-term impairment and potential to...
Automated scoring for a Tablet-based Rey Figure copy task differentiates constructional, organisational, and motor...
1.Critchley, M. The parietal lobes. (1953).2.Strauss, E., Sherman, E. M. S. & Spreen, O. A Compendium of neUropsychological Tests: Administration, Norms, and Commentary (American Chemical Society, 2006).
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Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to...
1.Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron. 1989;3:519–26.CAS
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Staging of Dementia Severity With the Hong Kong Version of the Montreal Cognitive Assessment...
Background:
The Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) has been used to screen for dementia, but it has not been validated to delineate the stages of Alzheimer disease (AD). This study aimed...
What does the sleeping brain think about? — ScienceDaily
We sleep on average one third of our time. But what does the brain do during these long hours? Using an artificial intelligence approach capable of decoding brain activity during sleep, scientists at the...
Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease
Purification and culture of aOPCs from the adult rat brainDensity gradients have often been used to purify microglia and hippocampal NSPCs from adult rodent brains (gradients spanning 1.030–1.065 g/ml in the case of microglia16,17,18 and...
Adapting Alzheimer Disease and Related Dementias Clinical Research Evaluations in the Age of COVID-19
In March 2020, the novel coronavirus (COVID-19) became a global pandemic that would cause most in-person visits for clinical studies to be put on pause. Coupled with protective stay at home guidelines, clinical research...
Synaptic plasticity depends on molecular hauler KIF5C, carrier of more than 650 RNAs, study...
The brain is wired for learning. With each experience, our neurons branch out to make new connections, laying down the circuitry of our long-term memories. Scientists call this trait plasticity, referring to an ability...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...