Melinda Parangan-Chu Selected as Manager of Education
The UC San Francisco Department of Radiology and Biomedical Imaging is delighted to announce the selection of Melinda Parangan-Chu as Manager of Education. She stepped into this new role on...
Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its...
Fig. 2The elevated cellular level of BACE1 is specific to BACE1 inhibitor treatment. (A) Intracellular BACE1 were measured by ELISA after 24-h treatment of HEK-293-sw cells with pepstatin A (doses from 790 nM to 50 μM). All...
New Funding Focuses on Prevention
The Alzheimer's Drug Discovery Foundation (ADDF) awarded three new investments that focus on prevention, including support of the HOPE4MCI Phase 3 trial.
"It is exciting to support a novel...
Screening older adults for amnestic mild cognitive impairment and early-stage Alzheimer’s disease using upper-extremity...
ParticipantsParticipants were recruited from the Banner Sun Health Research Institute (BSHRI) from September 2017 to May 2018. Eligible participants from the BSHRI cohort were vetted by the clinic director (KO) to assure eligibility for...
A Recap of UCSF Radiology at SNMMI 2019
The UC San Francisco Department of Radiology and Biomedical Imaging had a strong presence at the recent Society for Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting held June 22-25,...
Cost-effectiveness of a collaborative dementia care management—Results of a cluster-randomized controlled trial
Jump to Section1. Background2. Methods 2.1. The DelpHi trial 2.1.1. Design 2.1.2. Sample, participant flow, and drop out 2.2. Community-based, collaborative DCM versus usual care 2.3. Sociodemographic and clinical data 2.4. Health-related quality of life 2.5. Health-care resource uses and costs 2.6....
The ADDF and Harrington Discovery Institute Announce 2019 ADDF-Harrington Scholar Award
Harrington Discovery Institute at University Hospitals and the Alzheimer's Drug Discovery Foundation (ADDF) announce a joint request for proposals for the 2019 ADDF-Harrington Scholar Award. The ADDF-Harrington Scholar...
Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer’s disease
1.He, X., Huang, Y., Li, B., Gong, C. X. & Schuchman, E. H. Deregulation of sphingolipid metabolism in Alzheimer’s disease. Neurobiol Aging 31, 398–408, https://doi.org/10.1016/j.neurobiolaging.2008.05.010 (2010).2.Couttas, T. A. et al. Loss of the neuroprotective...
Dementia Reported Missing: Use of an Online Search Engine to Track Outcomes in Persons...
Background:
Persons with dementia (PWD) reported missing are known to be at high risk for mortality. Analysis of online search engines’ reports of missing PWD may show patterns in the data of this relatively...
Rahul Desikan, MD, PhD (1978-2019)
It is with a very heavy heart that I write to share the sad news that Rahul Desikan, MD, PhD passed away late yesterday afternoon after a 2 ½ year,...
Latest article
Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...