Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
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HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
Mouse strainsAll mouse work was approved by the Committee for Animal Care of the Division of Comparative Medicine at Massachusetts Institute of Technology. Hdac1f/f mice were gifted from E.N. Olson23. Hdac1f/f mice were bred...
A unified neurocognitive model of semantics language social behaviour and face recognition in semantic...
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Revisiting atherosclerosis and dementia | Nature Neuroscience
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What Does It Mean to Be A JCAHO Comprehensive Stroke Center?
UC San Francisco is the only JCAHO Comprehensive Stroke Center in San Francisco. What does this mean? According to Steven Hetts, MD, chief of Interventional Neuroradiology at the UCSF Mission...
A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains...
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Safety and Tolerability of the Rivastigmine Patch: Results of a 28-week Open-label Extension
The primary objective of the open-label extension was to evaluate the long-term safety and tolerability of a transdermal rivastigmine patch up to 1 year, as a novel approach to treatment in Alzheimer disease. This...
Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21...
Animal housing and handlingAPPPS1-21 mice in a C57BL6Cj background were obtained from M. Jucker (University of Tubingen, Tubingen, Germany) and were housed in the animal research center facility at the University of Chicago. Mice...
Longitudinal Metabolic and Cognitive Changes in Mild Cognitive Impairment Patients
Advancements in clinical therapies have identified the need for biomarkers of early Alzheimer disease that distinguish the earliest stages of pathology and target those patients who are likely to gain the most benefit. The...
CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4...
1.Au, R., Piers, R. J. & Lancashire, L. Back to the future: Alzheimer’s disease heterogeneity revisited. Alzheimers Dement (Amst) 1, 368–370 (2015).2.Corder, E. H. et al. Gene dose of apolipoprotein E type 4 allele...