Vessel isolation and nuclei extraction for sequencing used to profile vascular and perivascular brain cell types

brain
Credit: Pixabay/CC0 Public Domain

A team of researchers from multiple institutions in the U.S. and Germany has developed a way to create a molecular map of the human blood-brain barrier. In their paper published in the journal Nature, the group describes how they created their map and what it revealed about disorders such as Alzheimer’s disease. The group has also published a Research Briefing regarding their work in the same journal issue.

As the researchers note, the vasculature system plays a major role in most brain diseases, yet it is still not very well understood. They suggest the reason for this is the lack of a molecular map of the vasculature of the

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