By Caroline Seydel
A UCLA-led study has uncovered new potential drug targets in the brains of patients with Alzheimer’s disease, an irreversible, untreatable form of dementia. By testing more than a thousand patient samples, the researchers identified changes in the brain that were broadly consistent, and therefore likely to be involved in the disease.
“This is the most comprehensive analysis in terms of the number of cases used that’s been done to really look at the Alzheimer’s disease proteome,” said Dr. Daniel Geschwind, UCLA’s Gordon and Virginia MacDonald Distinguished Professor of Neurology, Psychiatry, and Human Genetics.
The term “proteome” refers to the collection of protein molecules present in the body, in the same way that “genome” refers to all of a person’s genes. The researchers measured the amounts of different proteins in brain samples…
