Article title: Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease
Authors: Lucas A. C. Souza, Fatima Trebak, Veena Kumar, Ryousuke Satou, Patrick G. Kehoe, Wei Yang, Whitney Wharton, Yumei Feng Earley
From the authors: “Our data show a significant increase in [cerebrospinal fluid [Na+], but not plasma [Na+], in [hypertension] patients with a family history of [Alzheimer’s disease] that is positively correlated with [blood pressure], suggesting the potential importance of [cerebrospinal fluid] Na+, but not plasma Na+, in the development or maintenance of chronic human hypertension. Our findings thus support the biological plausibility of a functional relationship between high sodium in the [cerebrospinal fluid] and arterial pressure in humans, although the underlying mechanisms remain to be determined.”
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