Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential...
1.Braak H. & Del Tredici K. Alzheimer’s pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathol. 121, 589–595 (2011).2.Mohamed, N. V., Herrou, T., Plouffe, V., Piperno, N. & Leclerc, N. Spreading of tau pathology in Alzheimer’s...
N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy...
1.Barca, D. et al. Intellectual disability and epilepsy in Down syndrome. Maedica 9, 344–350 (2014).PubMed
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Old habit-controlling neurons may also help the brain learn new tricks — ScienceDaily
Imagine working on your computer and typing the same long password you have used for years to access your email. By habit, you perform this sequence almost unconsciously. But then, one day, you stumble...
Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular...
Development of probes to detect a second N-terminal cleavage site in NOTCH3We hypothesized that in addition to the first Asp-Pro sequence of NOTCH3, additional Asp-Pro sequences of the protein could be vulnerable to proteolysis....
Microglial activation and tau propagate jointly across Braak stages
1.Ising, C. et al. NLRP3 inflammasome activation drives tau pathology. Nature 575, 669–673 (2019).CAS
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Could this test equal a way to determine dementia risk? Study finds scores on...
People whose scores on a dementia risk test indicated a less brain-healthy lifestyle, including smoking, high blood pressure and a poor diet, may also have the following: lower scores on thinking skills tests, more...
Five UC Radiology Departments Highlight Diversity, Equity and Inclusion (DEI) Work
A recent collaborative project of the five University of California radiology departments – UC Davis, UCLA, UC Irvine, UC San Diego, and UC San Francisco – highlights some of the...
MNI-FTD templates, unbiased average templates of frontotemporal dementia variants
Prior to generating the average templates, the quality of the images (e.g. presence of image artifacts such as motion) as well as the linear and nonlinear registrations was visually assessed and 16 cases (2...
The role of genetics in neurodegenerative dementia: a large cohort study in South China
1.Jack, C. R. et al. Prevalence of biologically vs clinically defined alzheimer spectrum entities using the national institute on aging–Alzheimer’s association research framework. JAMA Neurol. 76, 1174 (2019).PubMed Central
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Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
1.GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet 396(10258), 1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...